RADseq, photo: Ed Krosmicki

Population Genomics

Genomic tools have revolutionized biology and our ability to understand genetic processes in natural populations. Our lab studies a wide range of questions in population genomics, including the genetics of adaptation, population structure and phylogeography, disease resistance, the genetic basis of complex phenotypes, and demographic reconstruction. We use a common set of molecular techniques such as Restriction site-Associated DNA sequencing (RADseq) and whole-genome sequencing, combined with computational and bioinformatic tools, in species such as pygmy rabbits, threespine stickleback, trout, tamarisk leaf beetles, capybaras, wolves, Channel Island foxes, Gobi bears, and more.

Experimental Population Genomics

Experimental Evolution

The explosion of population genomic data from non-model organisms, made possible by techniques like RADseq, has outstripped our understanding of genomic evolution and our ability to make sense of the data. To bridge this gap, we are combining experimental evolution in yeast with next-generation sequencing. Here we can control population sizes, migration rates, strengths of selection, recombination rates, and amount and structure of standing genetic variation in replicated experiments, and observe the results of evolution at the genomic sequence level. The goal is to improve our powers of inference about natural populations from population genomic data.

Conservation Genomics

Conservation

Evolutionary genomic approaches have powerful applications to conservation of species and ecosystems. We use genomic tools to develop large sets of genetic markers, assess phylogeographic structure, detect hybridization and introgression, and understand the genetic basis of wildlife disease. For example we are collaborating on a genomic study of the evolution and epidemiology of Tasmanian devil facial tumor disease, a unique transmissible cancer, that poses a serious threat of extinction for this iconic species. Our goal is to identify genetic variation in devil populations associated with disease progression and inform species management. Other conservation projects address the remarkably high incidence of cancer in one population of island foxes, hybridization and genetic rescue in Columbia Basin pygmy rabbits, and genetic monitoring of harvested Idaho gray wolves.

Evolutionary Theory

Evolutionary Theory

Members of the lab are involved in several projects developing novel theory, analytical tools, or simulation approaches to understand evolutionary processes. For example, we are studying the relationship between genetic regulatory networks and the structure of variation in complex multivariate phenotypes (i.e. the M and G matrices of quantitative genetics). We have also developed a novel method for estimating the dimensionality of evolution that is widely applicable to mate choice and reproductive isolation, local adaptation, host-parasite coevolution, and other scenarios.